The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).

Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden. Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland. Department of Psychology, University of Cambridge, Cambridge, UK. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK. Faculté de Médecine, INSERM-University of Toulouse UMR1295 (CERPOP), Toulouse, France. Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France. Center for Life Course Health Research, University of Oulu, Oulu, Finland. Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Joint municipal authority for North Karelia social and health services (Siun sote), Joensuu, Finland. Finnish Institute of Occupational Health, Helsinki, Finland. Department of Public Health and Welfare, Functioning and Service Needs Unit, Finnish Institute for Health and Welfare, Helsinki, Finland. Department of Social Psychological Sciences, Karlstad University, Karlstad, Sweden. Engineering Psychology, Luleå University of Technology, Luleå, Sweden. Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. Department of Public Health, University of Helsinki, Helsinki, Finland. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. South Ostrobothnia Central Hospital, Seinäjoki, Finland. Theme Aging, Karolinska University Hospital, Solna, Sweden.

Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022;(7):1325-1334

Other resources

Abstract

INTRODUCTION Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses). METHODS FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores. RESULTS Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function. DISCUSSION Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.

Methodological quality

Metadata